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Computer Simulator Package
(For the IBM PC286 or above, runs in MS-DOS or Windows 3.1/Windows95 or above)
Description |
Cat No. |
Price (£) |
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Computer Simulator Package |
EKP114 |
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This flexible and easy to use computer programme allows the user to investigate the effects of the various operating parameters in CE. The program can be used to display the simulated peaks of analytes chosen from a database of over 100 compounds. The programme simulates the effect of varying any of the numerous parameters that can be varied in the real life situation.
The database entry for each solute includes the pKa value and the electrophoretic mobility. The database can easily be updated to include user specific compounds.
Whenever the user makes a change to any of the operating parameters, the package immediately recalculates and displays the new simulated electropherogram.
The values of each variable can easily be changed using the comprehensive mouse controlled pull down menus. In addition to the simulated peaks the simulation reports migration time, resolution, electrical current, peak areas and electrophoretic mobility.
This package also includes a number of exercises that can be used in the following fashion with predetermined test mixtures.
The test mixtures used in the exercises include mixtures of acidic, basic and neutral compounds. A test mixture consisting of a compound together with trace level related impurities is also included. The user can enter details of their own compounds of interest in order to carry out user specific optimisations.
- Understanding the principles of CE and the effects of various operating parameters
- Method development aid for both free solution electrophoresis, MECC and now supports even Chiral separations
- Optimisation of method in terms of achieving the required resolution sensitivity, current level and analysis time
- Examine the robustness of a method by simultaneous adjustment of operating parameters
Example screen shot of the simulated separation of 10 different sulphonic acid compounds
The variable parameters include:
Electrolyte: Ionic strength, pH, additives, micellar additives, chiral additives
Capillary: Total length, length to detector, inner and outer diameter, zeta potential and capillary material type
Equipment: Detector type, applied voltage, polarity, injection volume (pressure and time), operating temperature and cooling mechanism
This program has been developed on a highly scientific basis with a full appreciation of the underlying CR principles (J. Chromatography)
Example screen shot of the simulated separation of several neutral hydrocarbon compounds by MECC
CE Training Aids
Description |
Cat No. |
Price (£) |
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Introduction to Capillary Electrophoresis |
EKP215 |
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 Intended for the new user or the analyst contemplating becoming a CE user, his book provides a clear introduction to the theory and Instrumentation for the various modes of CE. Sections include: Electrophoresis Terminology, Flow Dynamics and Resolution, Effects of Voltage and Temperature, and Approaches to Method Development. |
Introduction to the theory and application of Chiral Capillary Electrophoresis |
EKP216 |
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 This short volume provides a clearly written introduction to the various techniques employed in order to achieve chiral separations by CE. Separations by free solution CE, capillary get electrophoreses and MECC are covered. A section on method development is included. Example applications involving quantitation are also shown. |
Introduction to Quantitative Applications of CE in Pharmaceutical Analysis |
EKP217 |
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 Written practising CE specialists from Glaxo Smith Kline® Research and Development, this book discussed the benefits of using CE for drug impurity determination and main component assay. A section discussing validation considerations such as precision, reproducibility and robustness is also included. |
Micellar Electrokinetic Chromatography |
EKP218 |
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 Written by the leading pioneer of MECC, Professor Shigeru Terabe, this concise volume describes the principles of micellar electrokinetic chromatography. Sections include, sensitivity manipulation, enantiomeric separations and method optimisation. There are many illustrations and example separations |
Capillary Electrophoresis Guide Book |
EKP116 |
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| Edited by Dr. K. D. Altria Written by many of the leading researchers and innovators in the field of CE instrumentation and application, this book provides extensive hands on advice and guidance to enable both CE newcomers and experience researchers alike to develop and optimize their own CE separations with every assurance of success. |
Capillary Electrophoresis VHS Video An introduction to Principles and Practice by Prof. David Goodall and Dr Anne Hodgson (University of York) |
EKP118 |
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| This video explains how CE works and why it works, takes you inside the capillary using computer generated graphics and video microscopy of electromigration. Designed as a training aid for individual or group instruction, it will complement hands on experience with any CE apparatus. Available in English, French, German, Spanish and Italian. Formats: PAL, SECAM and NTSC |
PC Based Interactive Training Package |
EKP120 |
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Written by Dr. Dennis Saunders, of LC Resources, this comprehensive and easy to use training package not only provides the newcomer to CE with a sound basic knowledge of the CE essentials but can also be used as a useful refresher for the experienced CE analyst.
This highly graphical programme is suitable for self-learning exercises. The programme is divided into sections covering the important and essential background areas in CE including:
Principles of CE; Operating Procedures in CE; Detection Possibilities; Free Solution CE; Capillary Gel Electrophoresis; and Micellar Electrokinetic Capillary Chromatography.
Each section and subsection contains a number of attractive cartoons and graphics which are supported by descriptive text. The individual sections contain sufficient graphics and text to obtain an appreciation and understanding of the underlying theories, separation modes and operating principles of CE. Hidden text can be activated to obtain definitions of specific technical terms by a simple click of the mouse.
The programme also includes several simulators which demonstrate specific aspects such as the effect of pH variation in MECC and the operation of electro-kinetic injection. Also included is a useful bibliography of reference books and articles for further reading.
Basic concepts are explained through the use of colourful animations. |
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