CE Grade Cyclodextrins and Buffer Reagents
 
 
 
 These macrocyclic carbohydrate compounds are widely used as buffer additives to obtain chiral separations in CE. However, they can also be used to adjust the selectivity in non chiral applications. There are three naturally occurring forms a, ß and ? which have 6, 7 and 8 glucose units respectively. The structure of ß-cyclodextrin is shown below. The hydroxyl units on the top of the cyclodextrin are chirally positioned and have different interactions with solute enantiomers when they are included into the cyclodextrin cavities. The hydroxyl groups can be chemically derivatised to give a range of neutral ad ionic derivatives which give different chiral separations and are more water soluble than the naturally occurring forms.

Structure of ß- cyclodextrin
Neutral cyclodextrin derivatives most frequently used in CE are:

   - dimethyl- cyclodextrin
   - trimethyl- cyclodextrin
   - hydroxypropyl- cyclodextrin

The most commonly used ionic forms are:

   - cyclodextrin sulphonic acid
   - Carboxymethyl- cyclodextrin
   - amino- cyclodextrin

The shape of cyclodextrins is often represented as a cone shaped cavity s shown below:

In order to obtain high efficiency separation it is necessary that the cyclodextrins used as CE additives are extremely pure. Capital Analytical technologies offers a wide range of both natural and derivatised cyclodextrins at CE grade purity. In addition to the cyclodextrins listed below, other derivatives are available on request. Please contact our sales office for details. Capital Analytical Cyclodextrins Capital Analytical has a full range of many types of cyclodextrins too numerous to list in full. If the cyclodextrin you require is not listed below, please contact our technical sales office.

The cyclodextrins form inclusion complexes with the different enatiomers which result in a chiral separation being obtained. A range of different sized and chemically modified cyclodextrins are used to obtain the required chiral separation.

Elphodextrin starter kit
Not sure which chiral Selector apply to your racemaic mixture? Elphodextrin starter Kit contains everything you need for rapid method development in Chiral CE separations. Seven cyclodextrins with different cavity size and cavity environment help you to follow the right track in your way toward complete separation. After a maximum 13 runs you achieve separation - many require no further optimisation.

Method development protocal and a flow chart are included, making the kit a complete tool for finding the suitable group type of cyclodextrin for the develeopment and optimisation of separation you need for your particular analyte. (Ref. N. Roos et. al: J. Chromatography A 782(1997) 257-269)

The other Elphodex Kits contain wide variety of cyclodextrin derivatives for further optimisation of chiral separations. Choose Kit A, B or G with different cavity size or Acid and Phosphate Kit, when the use of ionic cyclodextrin is advantageous.

Contents

Part No.

Price £

  

Elphodextrin Starter Kit - 0.5g each of a, and gamma cyclodextrins, 0.5g dimethyl-ß- cyclodextrin, 0.5g 2-hydroxyproply-ß- cyclodextrin, 0.5g caboxymethyl- cyclodextrin, 0.5g monoamino- cyclodextrin

CYE7001

Elphodex A - , 2.5 g alpha-CD, 0.5 g methyl-alpha-CD, 0.5 g alpha-CD phosphate, 0.5 g permethyl-alpha-CD, 0.5 g (2-hydroxy)propyl-alpha-CD, 0.5 g carboxymethyl-alpha-CD, 0.5g alpa-CD phosphate

CYE70011

Elphodex B - 2.5g beta-CD, 0.5g permethyl-beta-CD, 0.5g methyl-beta-CD, 0.5g (2 hydroxy)Propyl-beta-CD, 0.5g carboxymethyl-beta-CD, 0.5g beta-CD phosphate

CYE70012

Elphodex G - 2.5g gamma-CD, 0.5g permethyl-gamma-CD, 0.5g (2 hydroxy)Propyl-gamma-CD, 0.5g carboxymethyl-gamma-CD, 0.5g gamma-CD phosphate

CYE70013

Elphodex Acid Kit - 0.5g Carboxymethyl-alpha-CD, 0.5g Carboxymethyl-beta-CD, 0.5g carboxymethyl-gamma-CD, 0.5g carboxyethyl-alpha-CD, 0.5g carboxyethyl-beta-CD, 0.5g carboxymethyl-gamma-CD

CYE70014

Elphodex Phosphate Kit - 0.5g alpha-CD Phosphate, low DS, 0.5g alpha-CD Phosphate, high DS, 0.5g beta-CD Phosphate, Low DS, 0.5g beta-CD phosphate, high DS, 0.5g gamma-CD phosphate, low DS, 0.5g gamma-CD phosphate, high DS

CYE70015


Type

Description

Qty

Cat No.

Price (£)

  

Natural Cyclodextrins

a - cyclodextrin 99%

5g

EKT522

Natural Cyclodextrins

a - cyclodextrin 99%

25g

EKT523

Natural Cyclodextrins

b - cyclodextrin 99%

5g

EKT524

Natural Cyclodextrins

b - cyclodextrin 99%

25g

EKT525

Natural Cyclodextrins

g - cyclodextrin 99%

1g

EKT526

Natural Cyclodextrins

g - cyclodextrin 99%

5g

EKT527

Modified Neutral Cyclodextrins

b - dimethyl cyclodextrin

5g

EKT528

Modified Neutral Cyclodextrins

b - dimethyl cyclodextrin

5g

EKT529

Modified Neutral Cyclodextrins

b - trimethyl cyclodextrin

5g

EKT530

Modified Neutral Cyclodextrins

b - trimethyl cyclodextrin

5g

EKT531

Modified Neutral Cyclodextrins

b - 2 - hydroxypropyl cyclodextrin

1g

EKT532

Modified Neutral Cyclodextrins

b - 2 - hydroxypropyl cyclodextrin

5g

EKT533

Ionic Modified Cyclodextrins

b-cyclodextrin phosphate

1g

EKT534

Ionic Modified Cyclodextrins

b-cyclodextrin phosphate

2.5g

EKT535

Ionic Modified Cyclodextrins

b - carboxy methyl cyclodextrin

1g

EKT536

Ionic Modified Cyclodextrins

b - carboxy methyl cyclodextrin

5g

EKT537

Ionic Modified Cyclodextrins

b - amino cyclodextrin

1 g

EKT538

Ionic Modified Cyclodextrins

b - amino cyclodextrin

5 g

EKT539

Water Soluble Neutral Cyclodextrins

a-cyclodextrin ACD

1g

CY-E-1001

Water Soluble Neutral Cyclodextrins

b-cyclodextrin BCD

1g

CY-E-2001

Water Soluble Neutral Cyclodextrins

g-cyclodextrin GCD

1g

CY-E-3001

Water Soluble Neutral Cyclodextrins

Acetyl-a-cyclodextrin (DS ~7) AcACD

1g

CY-E-1002.1

Water Soluble Neutral Cyclodextrins

Acetyl-b-cyclodextrin (DS ~7) AcBCD

1g

CY-E-2002.1

Water Soluble Neutral Cyclodextrins

Acetyl-g-cyclodextrin (DS ~8) AcGCD

1g

CY-E-3002.1

Water Soluble Neutral Cyclodextrins

Acetyl-a-cyclodextrin(DS~14-16)AcACD-HDS

1g

CY-E-1002.2

Water Soluble Neutral Cyclodextrins

Acetyl-b-cyclodextrin (DS ~15) AcBCD-HDS

1g

CY-E-2002.2

Water Soluble Neutral Cyclodextrins

Acetyl-g-cyclodextrin (DS ~17) AcGCD-HDS

1g

CY-E-3002.2

Water Soluble Neutral Cyclodextrins

Hexakis(2,3,6-tri-O-methyl)-a-cyclodextrin TRIMEA

1g

CY-E-1003

Water Soluble Neutral Cyclodextrins

Heptakis(2,3,6-tri-O-methyl)-b-cyclodextrin TRIMEB

1g

CY-E-2003

Water Soluble Neutral Cyclodextrins

Octakis(2,3,6-tri-O-methyl)-g-cyclodextrin TRIMEG

1g

CY-E-3003

Water Soluble Neutral Cyclodextrins

Heptakis(2,6-di-O-methyl)-b-cyclodextrin DIMEB

1g

CY-E-2004.0

Water Soluble Neutral Cyclodextrins

Heptakis(2,6-di-O-methyl)-b-cyclodextrin, isomeric purity >80 % DIMEB/P

1g

CY-E-2004.2

Water Soluble Neutral Cyclodextrins

Heptakis(2,6-di-O-methyl)-b-cyclodextrin, isomeric purity >95 % DIMEB/P

1g

CY-E-2004.3

Water Soluble Neutral Cyclodextrins

Heptakis(2,6-di-O-methyl)-b-cyclodextrin, isomeric purity >98 % DIMEB/P

1g

CY-E-2004.4

Water Soluble Neutral Cyclodextrins

Randomly methylated a-cyclodextrin (DS ~11) RAMEA

1g

CY-E-1004.1

Water Soluble Neutral Cyclodextrins

Randomly methylated b-cyclodextrin (DS ~13) RAMEB

1g

CY-E-2004.1

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-a-cyclodextrin (DS ~3) HPACD

1g

CY-E-1005.1

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-b-cyclodextrin (DS ~3) HPBCD

1g

CY-E-2005.1

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-g-cyclodextrin (DS ~3) HPGCD

1g

CY-E-3005.1

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-a-cyclodextrin (DS ~4.8) HPACD

1g

CY-E-1005.2

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-b-cyclodextrin (DS ~4.6) HPBCD

1g

CY-E-2005.2

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-g-cyclodextrin (DS ~4.8) HPGCD

1g

CY-E-3005.2

Water Soluble Neutral Cyclodextrins

(2-hydroxy)propyl-b-cyclodextrin (DS ~6.3) HPBCD

1g

CY-E-2005.3

Water Soluble Neutral Cyclodextrins

(2-hydroxy)ethyl-a-cyclodextrin (DS ~4) HEACD

1g

CY-E-1028.1

Water Soluble Neutral Cyclodextrins

(2-hydroxy)ethyl-b-cyclodextrin (DS ~4) HEBCD

1g

CY-E-2028.1

Water Soluble Neutral Cyclodextrins

(2-hydroxy)ethyl-g-cyclodextrin (DS ~4) HEGCD

1g

CY-E-3028.1

Water Soluble Neutral Cyclodextrins

6-O-monomaltosyl-b-cyclodextrin, isomeric purity >98 % G2BCD/P

1g

CY-E-2042.0

Water Soluble Neutral Cyclodextrins

6-O-maltosyl-b-cyclodextrin (DS ~1.5) G2BCD

1g

CY-E-2042.1

Water Soluble Ionic Cyclodextrins

Carboxymethyl-a-cyclodextrin (DS ~3) CMACD

1g

CY-E-1006.0

Water Soluble Ionic Cyclodextrins

Carboxymethyl-b-cyclodextrin (DS ~3) CMBCD

1g

CY-E-2006.0

Water Soluble Ionic Cyclodextrins

Carboxymethyl-g-cyclodextrin (DS ~3) CMGCD

1g

CY-E-3006.0

Water Soluble Ionic Cyclodextrins

Succinyl-a-cyclodextrin (DS ~3.5) SuACD

1g

CY-E-1007.0

Water Soluble Ionic Cyclodextrins

Succinyl-b-cyclodextrin (DS ~3.5) SuBCD

1g

CY-E-2007.0

Water Soluble Ionic Cyclodextrins

Succinyl-g-cyclodextrin (DS ~3.5) SuGCD

1g

CY-E-3007.0

Water Soluble Ionic Cyclodextrins

Carboxyethyl-a-cyclodextrin (DS ~3) CEACD

1g

CY-E-1012.0

Water Soluble Ionic Cyclodextrins

Carboxyethyl-b-cyclodextrin (DS ~3) CEBCD

1g

CY-E-2012.0

Water Soluble Ionic Cyclodextrins

Carboxyethyl-g-cyclodextrin (DS ~3) CEGCD

1g

CY-E-3012.0

Water Soluble Ionic Cyclodextrins

a-cyclodextrin phosphate sodium salt (DS~2-6) PACD-LDS

1g

CY-E-1017.1

Water Soluble Ionic Cyclodextrins

b-cyclodextrin phosphate sodium salt (DS ~2-6) PBCD-LDS

1g

CY-E-2017.1

Water Soluble Ionic Cyclodextrins

g-cyclodextrin phosphate sodium salt (DS ~2-6) PGCD-LDS

1g

CY-E-3017.1

Water Soluble Ionic Cyclodextrins

a-cyclodextrin phosphate sodium salt (DS ~6-10) PACD-HDS

1g

CY-E-1017.2

Water Soluble Ionic Cyclodextrins

b-cyclodextrin phosphate sodium salt (DS ~6-10) PBCD-HDS

1g

CY-E-2017.2

Water Soluble Ionic Cyclodextrins

g-cyclodextrin phosphate sodium salt (DS ~6-10) PGCD-HDS

1g

CY-E-3017.2

Water Soluble Ionic Cyclodextrins

6-monodeoxy-6-monoamino-b-cyclodextrin hydrochloride MoAMBCD

1g

CY-E-2024

Water Soluble Ionic Cyclodextrins

Succinyl-(2-hydroxy)propyl-a-cyclodextrin SuHPACD

1g

CY-E-1033

Water Soluble Ionic Cyclodextrins

Succinyl-(2-hydroxy)propyl-b-cyclodextrin SuHPBCD

1g

CY-E-2033

Water Soluble Ionic Cyclodextrins

Succinyl-(2-hydroxy)propyl-g-cyclodextrin SuHPGCD

1g

CY-E-3033

Water Soluble Ionic Cyclodextrins

Sulfopropyl-a-cyclodextrin (DS ~2) SPACD

1g

CY-E-1040.0

Water Soluble Ionic Cyclodextrins

Sulfopropyl-b-cyclodextrin (DS ~2) SPBCD

1g

CY-E-2040.0

Water Soluble Ionic Cyclodextrins

Sulfopropyl-b-cyclodextrin (DS ~4) SPBCD4

1g

CY-E-2040.1